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Celiac Disease and Autoimmunity: Review and Controversies

2013; Springer Science+Business Media; Volume: 13; Issue: 4 Linguagem: Inglês

10.1007/s11882-013-0352-1

1534-6315

Jolanda M. Denham, Ivor D. Hill,

Helicobacter pylori-related gastroenterology studies

Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. There is a strong linkage between CD and HLA-DQ2 and HLA-DQ8 haplotypes. Multiple case reports and small series suggest concordance between CD and other autoimmune disorders. This paper provides a brief overview of the pathogenesis of CD and reviews the literature regarding associations between CD and other autoimmune diseases, including the potential effects of gluten-free diet therapy on the prevention or amelioration of associated diseases.