Defining a Substrate‐Binding Model of a Polysialyltransferase
2013; Wiley; Volume: 14; Issue: 15 Linguagem: Inglês
10.1002/cbic.201300367
ISSN1439-7633
AutoresFriedrich Freiberger, Raphael Böhm, David Schwarzer, Rita Gerardy‐Schahn, Thomas Haselhorst, Mark von Itzstein,
Tópico(s)Bacterial Genetics and Biotechnology
ResumoHighly disciplined transfers: Polysialyltransferases are important enzymes responsible for the biosynthesis of α-linked polysialic acids. We used a multidisciplinary approach, and propose the first substrate-binding model for a bacterial polysialyltransferase. Furthermore, we identify key amino acid residues involved in catalysis. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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