Artigo Acesso aberto

Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps

2008; Baishideng Publishing Group; Volume: 14; Issue: 44 Linguagem: Inglês

10.3748/wjg.14.6835

ISSN

2219-2840

Autores

Ali̇ Karaman, Doğan Nasır Binici, Mehmet Eşref Kabalar, Züleyha Çalıkuşu,

Tópico(s)

Cancer Genomics and Diagnostics

Resumo

AIM:To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC).METHODS: We analyzed MN frequencies in 21 patients with CRC, 24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls.RESULTS: MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 ± 1.34, 3.58 ± 1.21 vs 1.97 ± 0.81, P < 0.001).However, there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05).Similarly, there was no difference in the MN frequency between NNP patients (2.06 ± 0.85) and controls (P > 0.05).CONCLUSION: Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC.

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