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Cell biology of Legionella pneumophila

1999; Elsevier BV; Volume: 2; Issue: 1 Linguagem: Inglês

10.1016/s1369-5274(99)80005-8

1879-0364

Joseph P. Vogel, Ralph R. Isberg,

Heme Oxygenase-1 and Carbon Monoxide

Legionella pneumophila is the causative agent of a potentially fatal form of pneumonia named Legionnaires' disease. L. pneumophila survives and replicates inside macrophages by preventing phagosome-lysosome fusion. A large number of L. pneumophila genes, called dot or icm, have been identified that are required for intracellular growth. It has recently been shown that the dot/icm genes code for a putative large membrane complex that forms a type IV secretion system used to alter the endocytic pathway.