Late onset Pneumocystis pneumonia in renal transplantation after long‐term immunosuppression with belatacept
2009; Wiley; Volume: 11; Issue: 2 Linguagem: Inglês
10.1111/j.1399-3062.2009.00366.x
ISSN1399-3062
AutoresMichael Haidinger, Manfred Hecking, Mazda Memarsadeghi, Thomas Weichhart, Johannes Werzowa, Walter H. Hörl, Marcus D. Säemann,
Tópico(s)Immunodeficiency and Autoimmune Disorders
ResumoInterference with T-cell function increases the risk of infections, especially during the early post-transplant period. Belatacept, a costimulation blocker, is currently being tested in phase III clinical trials. Here we report a renal transplant recipient who received belatacept and developed severe Pneumocystis jirovecii pneumonia (PCP) with fatal superinfections 4 years post transplant. Cytomegalovirus infection preceded PCP, which typically occurs in overimmunosuppressed patients, but has not yet been reported under T-cell costimulation blockade in transplant patients. This case illustrates the possibility of excessive immunosuppression even with a lymphocyte-specific regimen.
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