Portal de Periódicos da CAPES

Effect of selective vaccination on a decrease in the rate of hepatitis B virus‐positive Japanese first‐time blood donors

2009; Wiley; Volume: 19; Issue: 4 Linguagem: Inglês

10.1111/j.1365-3148.2009.00930.x

1365-3148

Akira Yoshikawa, Kazuyuki Suzuki, Aki Abe, Toru Tanaka, Kohei Yamaguchi, Toru Tanaka, Yoshihide Ishikawa, Kiyoshi Minegishi, Yuhko Gotanda, Hisao Yugi, Shigeharu Uchida, Masahiro Satake, Hiroyuki Mizoguchi, Kenji Tadokoro,

Vaccine Coverage and Hesitancy

summary . The government of Japan started a selective vaccination programme to prevent mother‐to‐infant infection by hepatitis B virus (HBV) since January 1986. The effect of the programme on first‐time blood donors has not been examined in detail. Data of first‐time blood donors aged 16–25 years from 1996 to 2007 were extracted from the Japanese Red Cross (JRC) donors' database. Principal component analysis (PCA) was used to visualize the birth‐year‐dependent group of rate of HBV‐positive donors. According to the birth of year, donors were divided into four groups by PCA. After the start of the programme, donors born in 1986–1989 comprised a single group. Before the start of the programme, three groups (1980, 1981–1984 and 1985) were identified. Although a significant time‐dependent decrease in the rate of HBV‐positive donors was observed before the start of the programme, a significant difference in the rate of HBV‐positive donors was observed around the start of the programme by regression analysis for 16–19‐year‐old first‐time blood donors. The selective vaccination programme has been effective to prevent the vertical transmission of HBV from the analysis of first‐time blood donors. On the other hand, vaccination of blood donors should be considered to reduce the risk of post‐transfusion HBV infection, because the horizontal transmission increases in HBV‐positive blood donors.