Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride) membranes for skeletal muscle tissue engineering
2013; Royal Society of Chemistry; Volume: 3; Issue: 39 Linguagem: Inglês
10.1039/c3ra43499k
ISSN2046-2069
AutoresPedro M. Martins, Sylvie Ribeiro, Clarisse Ribeiro, Vítor Sencadas, Andreia C. Gomes, Miguel Gama, S. Lanceros‐Méndez,
Tópico(s)Graphene and Nanomaterials Applications
ResumoThis work reports on the influence of polarization and morphology of electroactive poly(vinylidene fluoride), PVDF, on the adhesion and morphology of myoblast cells. Non-poled, "poled+" and "poled−" β-PVDF films were prepared by solvent casting followed by corona poling. Furthermore, random and aligned electrospun β-PVDF fiber mats were also prepared. It is demonstrated that negatively charged surfaces improve cell adhesion and proliferation and that the directional growth of the myoblast cells can be achieved by culturing the cell on aligned fibers. Therefore, the potential application of electroactive materials for muscle regeneration is demonstrated.
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