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Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain

2009; The Company of Biologists; Volume: 137; Issue: 1 Linguagem: Inglês

10.1242/dev.041699

1477-9129

Suewei Lin, Sen-Lin Lai, Hung‐Hsiang Yu, Takahiro Chihara, Liqun Luo, Tzumin Lee,

Plant Molecular Biology Research

Numb can antagonize Notch signaling to diversify the fates of sister cells. We report here that paired sister cells acquire different fates in all three Drosophila neuronal lineages that make diverse types of antennal lobe projection neurons (PNs). Only one in each pair of postmitotic neurons survives into the adult stage in both anterodorsal (ad) and ventral (v) PN lineages. Notably, Notch signaling specifies the PN fate in the vPN lineage but promotes programmed cell death in the missing siblings in the adPN lineage. In addition, Notch/Numb-mediated binary sibling fates underlie the production of PNs and local interneurons from common precursors in the lAL lineage. Furthermore, Numb is needed in the lateral but not adPN or vPN lineages to prevent the appearance of ectopic neuroblasts and to ensure proper self-renewal of neural progenitors. These lineage-specific outputs of Notch/Numb signaling show that a universal mechanism of binary fate decision can be utilized to govern diverse neural sibling differentiations.