Synthesis of peptides containing the β-substituted aminoethane sulfinamide or sulfonamide transition-state isostere derived from amino acids
1992; Elsevier BV; Volume: 33; Issue: 42 Linguagem: Inglês
10.1016/s0040-4039(00)60981-4
ISSN1873-3581
AutoresWilna J. Moree, Gijs A. van der Marel, Rob M. J. Liskamp,
Tópico(s)Organic and Inorganic Chemical Reactions
Resumoα-amino acids can be converted to homochiral β-substituted aminoethane sulfinamide or sulfonamide transition-state isosteres, which can be incorporated into peptides. These transition-state analogues e.g. the sulfonamide isostere of Phe-Phe will be used for the generation of catalytic antibodies as well as for the development of protease inhibitors.
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