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Association analyses identify six new psoriasis susceptibility loci in the Chinese population

2010; Nature Portfolio; Volume: 42; Issue: 11 Linguagem: Inglês

10.1038/ng.690

1546-1718

Liangdan Sun, Hui Cheng, Zaixing Wang, Anping Zhang, Peiguang Wang, Jinhua Xu, Qixing Zhu, Haisheng Zhou, Eva Ellinghaus, Furen Zhang, Xiong-ming Pu, Xueqin Yang, Jianzhong Zhang, Aie Xu, Rina Wu, Limin Xu, Lin Peng, Cynthia Helms, Yunqing Ren, Chi Zhang, Shumei Zhang, Rajan P. Nair, Hongyan Wang, Guo-shu Lin, Philip E. Stuart, Xing Fan, Gang Chen, Trilokraj Tejasvi, Pan Li, Jun Zhu, Zhiming Li, Hongmei Ge, Michael Weichenthal, Wen-Zheng Ye, Cheng Zhang, Songke Shen, Baoqi Yang, Yuanyuan Sun, Shanshan Li, Yan Lin, Jianhua Jiang, Cun-Tao Li, Rixin Chen, Juan Cheng, Xin Jiang, Peng Zhang, Weimin Song, Jin Tang, Haoqin Zhang, Li Sun, Jing Cui, Lijun Zhang, Biao Tang, Fei Huang, Qian Qin, Xiao-Ping Pei, Aimin Zhou, Limei Shao, Jian-Lan Liu, Fengyu Zhang, Wei‐Dong Du, André Franke, A. Bowcock, James T. Elder, Jianjun Liu, Sen Yang, Xuejun Zhang,

Asthma and respiratory diseases

Xue-Jun Zhang and colleagues report genome-wide association analyses identifying six new susceptibility loci in the Chinese population. We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10−8) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10−21) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 × 10−3 and P = 7.9 × 10−3, respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 × 10−3 and P = 1.5 × 10−3, respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.