Bacteriostatic and bactericidal activity of azithromycin against Haemophilus influenzae
1990; Oxford University Press; Volume: 25; Issue: suppl A Linguagem: Inglês
10.1093/jac/25.suppl_a.25
ISSN1460-2091
AutoresF. W. Goldstein, M. F. Emirian, Anne Coutrot, J. F. Acar,
Tópico(s)Cancer therapeutics and mechanisms
ResumoMacrolidc antibiotics, commonly used in upper and lower respiratory tract infections, are inconsistently active against Haemophilus influenzae . The new azalide, azithromycin, was compared with erythromycin and roxithromycin against this pathogen. Azithromycin (MIC range 0.06–1 mg/l) was four to eight times more potent than erythromycin (MIC range 0.5–8 mg/l) and roxithromycin (MIC range 0.5–16 mg/l). At 1 mg/l, 100% of the strains of H.influenzae were inhibited by azithromycin compared with 16% with erythromycin and 5% with roxithromycin. Azithromycin exhibited a rapid bactericidal effect, with a 99.9% kill at 4h. The MBC was equal to or up to four-times greater than the MIC.
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