Portal de Periódicos da CAPES

Transcriptional Augmentation: Modulation of Gene Expression by Scaffold/Matrix-Attached Regions (S/MAR Elements)

2000; Begell House; Volume: 10; Issue: 1 Linguagem: Inglês

10.1615/critreveukargeneexpr.v10.i1.90

2162-6502

Jürgen Bode, Craig J. Benham, Angela Knopp, Christian Mielke,

RNA Interference and Gene Delivery

For a long time S/MARs could only be characterized by the assays in vitro that led to their detection. Only recently a number of biological activities emerged that are common to most or all S/MARs that are detected by the classic procedures. This review focuses on the phenomenon of transcriptional augmentation that is found for genomically anchored or episomal genes and on a group of partially overlapping activities that are suited to maintain an episomal status. Further, it is attempted to correlate properties of the S/MAR-scaffold interaction with prominent or prototype protein binding partners.