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Real-Time Magnetic Resonance Imaging–Guided Focal Laser Therapy in Patients with Low-Risk Prostate Cancer

2010; Elsevier BV; Volume: 58; Issue: 1 Linguagem: Inglês

10.1016/j.eururo.2010.03.006

1873-7560

Orit E. Raz, Masoom A. Haider, Sean M. Davidson, Uri Lindner, Eugen Hlasny, Robert Weersink, Mark R. Gertner, Walter Kucharcyzk, Stuart A. McCluskey, John Trachtenberg,

Urinary Bladder and Prostate Research

Two patients with low-risk prostate cancer (PCa) were treated with outpatient in-bore magnetic resonance imaging (MRI)–guided focal laser ablation. The tumor was identified on MRI. A laser fiber was delivered via a catheter inserted through a perineal template and guided to the target with MRI. The tissue temperature was monitored during laser ablation by MRI thermometry. Accumulated thermal damage was calculated in real time. Immediate post-treatment contrast-enhanced MRI confirmed devascularization of the target. No adverse events were noted. MRI-guided focal laser therapy of low-risk PCa is feasible and may offer a good balance between cancer control and side effects.