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An example of life history antecedence in the European badger ( Meles meles ): rapid development of juvenile antioxidant capacity, from plasma vitamin E analogue

2013; Taylor & Francis; Volume: 25; Issue: 4 Linguagem: Inglês

10.1080/03949370.2013.767861

1828-7131

Kirstin Bilham, Simon Yung Wa Sin, Chris Newman, Christina D. Buesching, David W. Macdonald,

Rabbits: Nutrition, Reproduction, Health

AbstractThe way organisms cope with oxidative stress, to quench potentially toxic oxygen free radicals while maintaining oxygen species functionality, is crucial in shaping life-history traits. Antioxidant capacity plays an important role in this process. Here we use multi-model inference procedures to examine the age-class-dependent non-enzymatic antioxidant capacity of the European badger (Meles meles), testing non-enzymatic plasma antioxidant capacity and expressing the results as vitamin E analogue (VEA) equivalent units. Despite immaturity (ca 16 weeks old), cubs exhibited plasma antioxidant capacity equivalent to those of prime-age adults (1–5 years old). Compared to individuals aged 6 years and over, cubs exhibited significantly higher non-enzymatic plasma antioxidant capacity. There was no association between plasma antioxidant capacity and sex or other physiological variables, such as body condition or presence of wounding. We consider the adaptive significance of this life-history strategy with respect to pandemic endoparasitoses that affect badger cub survival, as well as a possible link to the free radical theory of ageing. Our finding on the interaction between age and antioxidant defences (linked to immune function) has implications for the controversy surrounding effective badger bovine tuberculosis management strategy in the UK.key words: antioxidantinnate immunityontogenyoxidative stressROSoxygen free radical AcknowledgementsWe thank the WildCRU's badger team, without whom this study would have been impossible, with special thanks for statistical support from Paul Johnson and supplementary input from Geetha Annavi. We also thank Adrian Smith and Aristophanes (Stephen) Georgiou for access to their spectrophotometry equipment. We thank Adrian Smith and Caroline Isaksson for advice and comments on this research. We thank an anonymous reviewer for helpful comments and suggestions.All trapping and handling procedures were approved by the Zoology ethical review panel at the University of Oxford and were in accord with the UK Animals (Scientific Procedures) Act, 1986. Work was carried out under Natural England Licenses, currently 20104655 and Home Office License PPL 30/2835.The authors have no conflict of interest regarding the material discussed in this manuscript.