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Trial of isotretinoin and calcitriol monitored by CA 125 in patients with ovarian cancer

1996; Springer Nature; Volume: 74; Issue: 9 Linguagem: Inglês

10.1038/bjc.1996.568

1532-1827

G.J.S. Rustin, Timothy Quinnell, Jeremy Johnson, Helen Clarke, Ann E. Nelstrop, Wendy B. Bollag,

Photodynamic Therapy Research Studies

Twenty-two asymptomatic women with rising CA 125 levels after chemotherapy for ovarian cancer were entered into a trial of isotretinoin combined with calcitriol. Tumours were evaluated according to precise criteria based on serial CA 125 levels and by comparing regression slopes of CA 125 before and during therapy. There was no evidence based on CA 125 of any responses or significant change in tumour growth rate.