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The effect of ethylenediaminetetraacetic acid (EDTA) and EDTA plus salicylate on acute cadmium toxicity and distribution

1980; Elsevier BV; Volume: 53; Issue: 3 Linguagem: Inglês

10.1016/0041-008x(80)90363-4

1096-0333

Louis R. Cantilena, Curtis D. Klaassen,

Immunotoxicology and immune responses

The lethality of various dosages of intravenously administered cadmium (as CdCl2) was tested in female Swiss Webster mice weighing 30–45 g which were given CaNa2-ethylenediaminetetraacetic acid (EDTA) (0.5 mmol/kg ip) or CaNa2EDTA plus sodium salicylate (SA, 2 mmol/kg ip) immediately after the Cd injection. In mice given saline instead of a chelator the LD50 for Cd was about 3.5 mg Cd/kg. Mice given either EDTA or EDTA + SA were protected from the lethal effects of Cd up to 5 mg Cd/kg. No difference in survival was found between animals treated with either EDTA + SA or EDTA alone at any dosage of Cd. The tissue concentrations of a sublethal dosage (1 mg Cd/kg) of radiolabeled Cd (109Cd) injected intraveneously were measured in blood, plasma, heart, lung, pancreas, spleen, small intestine, kidney, stomach, bone, brain, liver, and muscle of mice also treated with various dosages of EDTA with or without a fixed dosage of salicylate (2 mmol/kg). EDTA, in dosages as low as 0.3 mmol/kg, significantly decreased the concentration of Cd found in most tissues. The addition of sodium salicylate to the chelator therapy did not significantly alter tissue Cd concentrations when compared to that found in mice given EDTA alone.