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Catalytic Asymmetric Addition of Terminal Alkynes to Aldehydes Mediated by (1 R ,2 R )‐2‐(Dimethylamino)‐ 1,2‐diphenylethanol

2005; Wiley; Volume: 347; Issue: 11-13 Linguagem: Inglês

10.1002/adsc.200505157

1615-4169

Mitsuaki Yamashita, Ken‐ichi Yamada, Kiyoshi Tomioka,

Asymmetric Hydrogenation and Catalysis

Abstract Catalytic asymmetric alkynylation of aldehydes with terminal alkynes was catalyzed by zinc triflate and (1 R ,2 R )‐2‐(dimethylamino)‐1,2‐diphenylethanol in toluene to give the corresponding alcohols with high enantiomeric excess up to 98% in good yields.