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Relative Increase of T Cells Expressing the Gamma/Delta Rather Than the Alpha/Beta Receptor in Ataxia-Telangiectasia

1990; Massachusetts Medical Society; Volume: 322; Issue: 2 Linguagem: Inglês

10.1056/nejm199001113220201

1533-4406

Maurizio Carbonari, M. Cherchi, Roberto Paganelli, Giuseppe Giannini, Elena Galli, Carlo Gaetano, C Papetti, Massimo Fiorilli,

DNA Repair Mechanisms

In ataxia—telangiectasia, B-cell and T-cell deficiencies are thought to be due to a defect of rearrangements of immunoglobulin and T-cell receptor genes. T cells recognize antigens through two types of CD3-associated receptors: α/β chains on mature cells and γ/δ chains mostly on immature cells.