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Anticarcinoma Activity in Vivo of Rhodamine 123, a Mitochondrial-Specific Dye

1983; American Association for the Advancement of Science; Volume: 222; Issue: 4620 Linguagem: Inglês

10.1126/science.6623064

1095-9203

Samuel D. Bernal, Théodore J. Lampidis, Robert M. McIsaac, Lan Bo Chen,

Inflammatory mediators and NSAID effects

Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.