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The surgical dilemma in the primary therapy of invasive breast cancer: A critical appraisal

1970; Elsevier BV; Volume: 7; Issue: 10 Linguagem: Inglês

10.1016/s0011-3840(70)80007-7

1535-6337

Bernard Fisher,

Inflammatory mediators and NSAID effects

Management of breast cancer has always been informed by our understanding of the biology of this disease. As we moved from descriptive models to biologically grounded models, we began designing treatments that take advantage of the weaknesses of this cancer. The hallmark of this cancer is its heterogeneity between patients and within the same patients at different stages of the disease. Traditional classifiers and modern genomic tools allow the classification of breast cancer into subtypes that instruct its treatment that has become extremely different from one type to the other and from one patient to the other. Surgery has become less invasive and radiation therapy less toxic. Chemotherapy, hormonal therapy, targeted therapy and immunotherapy have resulted in dramatic improvement of outcomes for many patients and has led to decreased mortality in the face of increasing incidence of the disease. This chapter addresses our new understanding of breast cancer and highlights the major advances in its treatment.