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Electrophilicity and Nucleophilicity Index for Radicals

2007; American Chemical Society; Volume: 9; Issue: 14 Linguagem: Inglês

10.1021/ol071038k

1523-7060

Freija De Vleeschouwer, Véronique Van Speybroeck, Michel Waroquier, Paul Geerlings, Frank De Proft,

Organic Chemistry Cycloaddition Reactions

Radicals can be regarded as electrophilic/nucleophilic, depending on their tendency to attack sites of relatively higher/lower electron density. In this paper, an electrophilicity scale, global as well as local, and a nucleophilicity scale for 35 radicals is reported. The global electrophilicity scale correlates well with the nucleophilicity scale, suggesting that these concepts are inversely related.