Portal de Periódicos da CAPES

Formulation and in vitro evaluation of HPMCP-microencapsulated drug-resin complexes for sustained release of diclofenac

1995; Elsevier BV; Volume: 121; Issue: 2 Linguagem: Inglês

10.1016/0378-5173(95)00020-j

1873-3476

Dolores Torres, Gregorio García-Encina, Begoña Seijo, José Luis Vila Jato,

Advanced Polymer Synthesis and Characterization

Microcapsules containing diclofenac-resin complexes were prepared by a non-aqueous emulsion method using hydroxypropyl methylcellulose phthalate (HPMCP). The effect of the addition of various surfactants on the characteristics of microcapsules including resin particles with different degrees of crosslinking, was investigated. The microencapsulation process was evaluated with respect to total yield and coat to core ratio, and the microcapsules with respect to particle size and dissolution efficiency. Statistical analysis of the results demonstrated that both the degree of crosslinking and the presence of the polymer coating significantly retard release, indicating that the effect of the type of surfactant on the release rate is inappreciable.