Produção Nacional
Revisado por pares
Effect of Lycopene on Nephrotoxicity Induced by Mercuric Chloride in Rats
2007; Wiley; Volume: 100; Issue: 6 Linguagem: Inglês
10.1111/j.1742-7843.2007.00067.x
ISSN1742-7843
AutoresPaula Rossini Augusti, Greicy M. M. Conterato, Sabrina Somacal, Lídia Einsfeld, Adriano Tony Ramos, Fernando Yutaka Moniwa Hosomi, Dominguita Lühers Graça, Tatiana Emanuelli,
Tópico(s)Dye analysis and toxicity
ResumoAbstract: Oxidative stress is an important molecular mechanism for kidney injury in mercury poisoning. We studied lycopene, a potent carotenoid found in tomatoes due to its large antioxidant properties, and also evaluated the ability of lycopene to prevent HgCl 2 nephrotoxicity. Rats were injected with HgCl 2 (0 or 5 mg/kg body weight, subcutaneously) 6 hr after lycopene administration (0, 10, 25 or 50 mg/kg by gavage) and were killed 12 hr after HgCl 2 exposure. HgCl 2 ‐induced inhibition of δ‐aminolevulinate dehydratase activity (∼35%) and increase of lipid peroxidation in kidney (∼37%) were prevented by lycopene. However, lycopene did not prevent the increase of plasma creatinine levels (∼123%) and renal tubular necrosis induced by HgCl 2 . Glutathione peroxidase and catalase activities were enhanced (∼71% and ∼41%), while superoxide dismutase activity was depressed (∼44%) in HgCl 2 ‐treated rats when compared to control and these effects were prevented by lycopene. Our results indicate that although lycopene did not prevent HgCl 2 ‐induced renal failure, it could play a beneficial role against HgCl 2 toxicity by preventing lipid peroxidation and changes in the activity of δ‐aminolevulinate dehydratase and antioxidant enzymes.
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