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BIBTEX RIS

Halogen atom effect on photophysical and photodynamic characteristics of derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin

2008; Elsevier BV; Volume: 92; Issue: 1 Linguagem: Inglês

10.1016/j.jphotobiol.2008.04.006

ISSN

1873-2682

Autores

Arménio C. Serra, Marta Piñeiro, Α. Μ. d’A. Rocha Gonsalves, Ana Margarida Abrantes, Mafalda Laranjo, Ana C. Santos, Maria Filomena Botelho,

Tópico(s)

Nanoplatforms for cancer theranostics

Resumo

Brominated and iodinated derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin were synthesised directly from the corresponding aldehydes. Photophysical and photochemical properties, singlet oxygen formation quantum yields, photobleaching and log P were measured. Cellular uptake measurements and cytotoxicity assays on WiDr and A375 tumour cell lines were performed. 5,10,15,20-Tetrakis(2-bromo-5-hydroxyphenyl)porphyrin showed the best cytotoxicity with values of IC50 of 113 nM over WiDr cells and 52 nM over A375 cells.

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