Portal de Periódicos da CAPES

The Induction of Chromosome Abnormalities by Melphalan in Rat Bone Marrow Cells

1973; Wiley; Volume: 11; Issue: 2 Linguagem: Inglês

10.1111/j.1600-0609.1973.tb00107.x

0036-553X

Gunhild Lange Wantzin, Mogens Krogh Jensen,

Biopolymer Synthesis and Applications

The cytogenetic effect of melphalan was studied in bone marrow cells of Wistar rats in vivo. Melphalan produces structural aberrations of the chromatid and chromosome type, whereas no numerical aberrations were seen. The proportion of abnormal metaphases varied with the period that had elapsed since the administration of melphalan. Repeated large doses of melphalan were not able to produce permanent damage to the chromosome complement.