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Conditional inactivation of the calbindin D‐28k ( Calb1 ) gene by Cre/ loxP ‐mediated recombination

2002; Wiley; Volume: 32; Issue: 2 Linguagem: Inglês

10.1002/gene.10045

1526-968X

J.J. Barski, Karin Mörl, Michaël Meyer,

Photosynthetic Processes and Mechanisms

genesisVolume 32, Issue 2 p. 165-168 ArticleFree Access Conditional inactivation of the calbindin D-28k (Calb1) gene by Cre/loxP-mediated recombination Jaroslaw J. Barski, Corresponding Author Jaroslaw J. Barski [email protected] Max-Planck-Institute of Neurobiology, Martinsried, Germany Medical University of Silesia, Department of Physiology, Katowice, PolandMax-Planck-Institute of Neurobiology, Dept. of Neurobiochemistry, Am Klopferspitz 18A, D-82152 Martinsried, GermanySearch for more papers by this authorKarin Mörl, Karin Mörl Max-Planck-Institute of Neurobiology, Martinsried, GermanySearch for more papers by this authorMichael Meyer, Michael Meyer Max-Planck-Institute of Neurobiology, Martinsried, Germany Institute of Ophthalmology, University College London, London, United KingdomSearch for more papers by this author Jaroslaw J. Barski, Corresponding Author Jaroslaw J. Barski [email protected] Max-Planck-Institute of Neurobiology, Martinsried, Germany Medical University of Silesia, Department of Physiology, Katowice, PolandMax-Planck-Institute of Neurobiology, Dept. of Neurobiochemistry, Am Klopferspitz 18A, D-82152 Martinsried, GermanySearch for more papers by this authorKarin Mörl, Karin Mörl Max-Planck-Institute of Neurobiology, Martinsried, GermanySearch for more papers by this authorMichael Meyer, Michael Meyer Max-Planck-Institute of Neurobiology, Martinsried, Germany Institute of Ophthalmology, University College London, London, United KingdomSearch for more papers by this author First published: 13 February 2002 https://doi.org/10.1002/gene.10045Citations: 12AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL LITERATURE CITED Airaksinen MS, Eilers J, Garaschuk O, Thoenen H, Konnerth A, Meyer M. 1997a. Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin d28k gene. Proc Natl Acad Sci U S A 94: 1488– 1493. Airaksinen MS, Thoenen H, Meyer M. 1997b. Vulnerability of midbrain dopaminergic-neurons in calbindin-d-28k-deficient mice—lack of evidence for a neuroprotective role of endogenous calbindin in mptp-treated and weaver mice. Eur J Neurosci 9: 120– 127. Baimbridge KG, Celio MR, Rogers JH. 1992. Calcium-binding proteins in the nervous system. Trends Neurosci 15: 303– 308. Barski JJ, Dethleffsen K, Meyer M. 2000. Cre recombinase expression in cerebellar Purkinje cells. genesis 28: 93– 98. Celio MR. 1990. Calbindin D-28k and parvalbumin in the rat nervous system. Neuroscience 35: 375– 475. Christakos S, Gabrielides C, Rhoten WB. 1989. Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations, and molecular biology. Endocr Rev 10: 3– 26. Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K. 1994. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265: 103– 106. Heizmann CW, Hunziker W. 1991. Intracellular calcium-binding proteins: more sites than insights. Trends Biochem Sci 16: 98– 103. Jouvenceau A, Potier B, Battini R, Ferrari S, Dutar P, Billard JM. 1999. Glutamatergic synaptic responses and long-term potentiation are impaired in the CA1 hippocampal area of calbindin D-28K-deficient mice. Synapse 33: 172– 180. Klapstein GJ, Vietla S, Lieberman DN, Gray PA, Airaksinen MS, Thoenen H, Meyer M, Mody I. 1998. Calbindin-d-28k fails to protect hippocampal-neurons against ischemia in spite of its cytoplasmic calcium buffering properties—evidence from calbindin-d-28k knockout mice. Neuroscience 85: 361– 373. Le Y, Sauer B. 2000. Conditional gene knockout using cre recombinase. Methods Mol Biol 136: 477– 485. Persechini A, Moncrief ND, Kretsinger RH. 1989. The EF-hand family of calcium-modulated proteins. Trends Neurosci 12: 462– 467. Schmidt EE, Taylor DS, Prigge JR, Barnett S, Capecchi MR. 2000. Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc Natl Acad Sci U S A 97: 13702– 13707. Sternberg N, Hamilton D. 1981. Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. J Mol Biol 150: 467– 486. Citing Literature Volume32, Issue2Special Issue: Conditional Alleles in MiceFebruary 2002Pages 165-168 ReferencesRelatedInformation