Pathology of asthma
1993; Elsevier BV; Volume: 92; Issue: 1 Linguagem: Inglês
10.1016/0091-6749(93)90029-f
ISSN1097-6825
Autores Tópico(s)Pleural and Pulmonary Diseases
ResumoThe postmortem changes in the lungs of patients with severe asthma were well known in Osler’s time.‘, ’ One of the most obvious features is hyperinflation of the lung due to air trapping beyond widespread plugging of segmental and subsegmental airways.3-‘o Histologic examination of these airways (Fig. 1) shows that the plugs that often fill the lumen consist of an inflammatory exudate made up of plasma proteins and inflammatory cells, particularly eosinophils, that have migrated into the lumen and wall of the airway. This exudate also contains epithelial cells, which have sloughed from the airway surface, and small amounts of mucus derived from the goblet cells and mucous glands. The sloughed epithelial cells leave a partially denuded airway surface with evidence of regeneration of the epithelium by goblet and squamous cell metaplasia. At the light microscopic level there is usually a marked thickening of the basement membrane on which the epithelium sits (Fig. 1). However, this change in
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