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Trimetazidine Improves Myocardial Perfusion and Left Ventricular Function in Ischemic Left Ventricular Dysfunction

2004; Lippincott Williams & Wilkins; Volume: 29; Issue: 2 Linguagem: Inglês

10.1097/01.rlu.0000109298.69905.04

1536-0229

Mauro Feola, Alberto Biggi, Antonella Francini, Giovanni Leonardi, Flavio Ribichini, Valeria Ferrero, E Uslenghi,

Cardiac Structural Anomalies and Repair

Trimetazidine (TMZ) has an antiischemic effect unrelated to changes in myocardial oxygen supply-to-demand ratio. TMZ improves energy metabolism during ischemia and protects myocardial cells against ischemic damage to mitochondrial function. The preserved mitochondrial metabolism might explain the increased cardiac uptake of Tc-99m tetrofosmin or Tc-99m sestamibi on myocardial SPECT in patients with coronary artery disease. Oral administration of TMZ might improve myocardial uptake of Tc-99m tetrofosmin and left ventricular function in ischemic cardiac dysfunction. Treatment with TMZ before myocardial Tc-99m tetrofosmin SPECT could help in revealing hibernating myocardium.