Evidence of increased non-adrenoceptor [3H]idazoxan binding sites in the frontal cortex of depressed suicide victims
1993; Elsevier BV; Volume: 34; Issue: 7 Linguagem: Inglês
10.1016/0006-3223(93)90243-7
ISSN1873-2402
AutoresJ. Javier Meana, Fernando Barturen, Iñaki Martín, Jesús A. García‐Sevilla,
Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoHyperactivity of inhibitory ct2-adrenoeeptors has been postulated in the pathogenesis of endogenous depression (Garefa-Sevilla 2989). This hypothesis was initially supported by the finding that depressed patients show supersensitive ~2-adrenoceptors in blood platelets (Garcfa-Sevilla et al 1986; Piletz et al 1991) and recently by the direct evidence of an increased number and affinity of o2-adrenoceptors ([3H]clonidine, [3H]UK 24304 and [3H]idazoxan binding) in the brain of depressed suicide victims (M~ana et al 1992). These imidazoline derivatives not oldy possess high affinity for the ot2-adrenoceptor but also for non-adrenoceptor imidazoli(di)ne/guanidine-pmferring sites in the human brain (Bricca et al 1989; Convents et al 2989; De Vos et al 1991). These putative imidazoline receptors are involved in central regulation of blood pressure (Tibiri~a et al 1991) and mediate inhibitory effects on norepinephrine release in sympathetic nerve terminals (G6thert and Molderings 1992', Molderings et al 1991). The aim of the present study was to examine in more detail the binding properties of [~H]idazoxan in the brain of depressed suicide victims to quantitate simultaneously ot2-adrenoceptors and non-adrenoceptor [3Hlidazoxan binding sites (NAIBS), This investigation is an extension and refinement of a particular set ofexperiments previously reported (Meana et a! !992). However, the concepts and data presented here are new.
Referência(s)