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Genetic Interactions in Cancer Progression and Treatment

2011; Cell Press; Volume: 145; Issue: 1 Linguagem: Inglês

10.1016/j.cell.2011.03.020

1097-4172

Alan Ashworth, Christopher J. Lord, Jorge S. Reis‐Filho,

DNA Repair Mechanisms

As cancer cell genomes are unveiled at a breathtaking pace, the genetic principles at play in cancer are emerging in all their complexity, prompting the assessment of classical genetic interaction models. Here, we discuss the implications of these findings for cancer progression and heterogeneity and for the development of new therapeutic approaches.