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CYTOGENETIC STUDIES IN HAEMATOLOGICAL DISORDERS WHICH MAY TERMINATE IN ACUTE LEUKAEMIA

1973; Wiley; Volume: 193; Issue: 1-6 Linguagem: Inglês

10.1111/j.0954-6820.1973.tb10590.x

0001-6101

Mogens Krogh Jensen, Preben Philip,

Acute Lymphoblastic Leukemia research

Abstract Cytogenetic studies have been performed in 35 patients with potentially leukaemic haematological disorders. Abnormal stem lines were present in six patients, three of whom died from leukaemia or aggressive myelofibrosis within a few months. One patient developed leukaemia more than four years after the demonstration of the abnormal stem line. The chromatin of the abnormal bone marrow metaphases from the patients had a blurred appearance. The remaining two patients survived for 22 and 39 months without evidence of leukaemia. In these cases the chromatin structure of the marrow metaphases had a normal appearance. Three of the 29 cytogenetically normal patients developed leukaemia. It is concluded that the abnormal stem lines may be considered leukaemic clones of cells. However, a few patients may survive for months or years. The appearance of the chromatin structure of the bone marrow metaphases seems to be of prognostic significance. Finally, evidence is given that the chromosome abnormalities are present in both cells from the granulocytic cell line and the erythroblasts of the bone marrow.