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Studies on the etiology of exanthema subitum (roseola infantum)

1950; Elsevier BV; Volume: 37; Issue: 4 Linguagem: Inglês

10.1016/s0022-3476(50)80266-4

1097-6833

C. Henry Kempe, Edward B. Shaw, Jocelyn. Jackson, Henry K. Silver,

Influenza Virus Research Studies

Summary 1.The first experiment described has persuasively demonstrated the infectious nature of exanthema subitum, by means of a transmission experiment from a human donor to a susceptible subject. 2.Subsequent experiments utilizing monkeys have demonstrated the presence of a fever-producing agent in the serum of human beings on the third day of the febrile period of exanthema subitum illness, as well as in the throat washings of a susceptible recipient. It also was shown to be present in the serum of previously infected monkeys. This fever-producing agent has not been shown to be present in the blood of human patients during the first day of the febrile period. 3.The challenge experiments have shown that blood taken on the third day of the febrile period of exanthema subitum was still able to produce a febrile disease in control monkeys, but failed to do so in monkeys previously experiencing a febrile inoculation disease. 4.Egg passage material has, to date, failed to produce febrile reactions in four monkeys tested. Summary 1.The first experiment described has persuasively demonstrated the infectious nature of exanthema subitum, by means of a transmission experiment from a human donor to a susceptible subject. 2.Subsequent experiments utilizing monkeys have demonstrated the presence of a fever-producing agent in the serum of human beings on the third day of the febrile period of exanthema subitum illness, as well as in the throat washings of a susceptible recipient. It also was shown to be present in the serum of previously infected monkeys. This fever-producing agent has not been shown to be present in the blood of human patients during the first day of the febrile period. 3.The challenge experiments have shown that blood taken on the third day of the febrile period of exanthema subitum was still able to produce a febrile disease in control monkeys, but failed to do so in monkeys previously experiencing a febrile inoculation disease. 4.Egg passage material has, to date, failed to produce febrile reactions in four monkeys tested.