Age-related changes in human muscarinic acetylcholine receptors measured by positron emission tomography
1993; Elsevier BV; Volume: 149; Issue: 2 Linguagem: Inglês
10.1016/0304-3940(93)90777-i
ISSN1872-7972
AutoresTetsuya Suhara, Osamu Inoue, Kaoru Kobayashi, Kazutoshi Suzuki, Yukio Tateno,
Tópico(s)Ion channel regulation and function
ResumoThe effects of age on the binding parameters of [11C]N-methyl-4-piperidylbenzilate ([11C]NMPB), a specific muscarinic cholinergic receptor ligand, were studied. Eighteen healthy male volunteers (18–75 years old) participated. Regional radioactivity in the brain was followed for 60 min by positron emission tomography (PET). Uptake of [11C]NMPB continuously increased in all brain areas with the exception of the cerebellum. For the quantification of receptor binding, a compartment model, in which radioactivity in the cerebellum was used as an input function, was used. The binding parameter, K3, of muscarinic acetylcholine receptors in eight brain regions (pons, hippocampus, frontal cortex, striatum, temporal cortex, thalamus, occipital cortex, parietal cortex) showed an age-related decrease of about 45% over the age range.
Referência(s)