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Neuregulin 1-alpha expression in locally advanced breast cancer

2001; Elsevier BV; Volume: 10; Issue: 1 Linguagem: Inglês

10.1054/brst.2000.0182

1532-3080

E. Hemanth Raj, Ann Skinner, Urmila Mahji, K. Nirmala, Kodi S. Ravichandran, V. Shanta, Helen C. Hurst, William J. Gullick, Thangarajan Rajkumar,

Glycosylation and Glycoproteins Research

The human Neuregulin 1 (NRG1) gene encodes several alternatively spliced ligands that bind to both c-erbB-3 and c-erbB-4, members of the family of type 1 tyrosine kinase growth factor receptors. Antibodies raised to a synthetic peptide recognize selectively the alpha variant of NRG1. The NRG1-alpha isoforms' expression was studied in 115 locally advanced adenocarcinomas of the breast using immunohistochemistry. Absent or low levels of NRG1-alpha were found to be associated with poorer prognosis compared to tumours that had moderate to high levels of the protein.