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Control of mitosis by changes in the subcellular location of cyclin-B1–Cdk1 and Cdc25C

2000; Elsevier BV; Volume: 12; Issue: 6 Linguagem: Inglês

10.1016/s0955-0674(00)00149-6

1879-0410

Catherine G. Takizawa, David O. Morgan,

Genomics and Chromatin Dynamics

Nuclear events of mitosis are initiated when the protein kinase cyclin-B1–Cdk1 is translocated into the nucleus during prophase. Recent work has unveiled many of the mechanisms that govern the localization of cyclin-B1–Cdk1 and its regulator Cdc25C. Phosphorylation-dependent changes in the rate of nuclear import and export of these proteins help to control the onset of mitosis both in normal cells and in cells delayed before mitosis by DNA damage.