Oxidative DNA damage in rats exposed to extremely low frequency electro magnetic fields
2005; Taylor & Francis; Volume: 39; Issue: 3 Linguagem: Inglês
10.1080/10715760500043603
ISSN1071-5762
AutoresBeran Yokuş, Dilek Ülker Çakır, Mehmet Zülküf Akdağ, Cemil Sert, Nuriye Mete,
Tópico(s)Air Quality and Health Impacts
ResumoAbstractExtremely low frequency (ELF) electromagnetic field (EMF) is thought to prolong the life of free radicals and can act as a promoter or co-promoter of cancer. 8-hydroxy-2′-deoxyguanosine (8OHdG) is one of the predominant forms of radical-induced lesions to DNA and is a potential tool to asses the cancer risk. We examined the effects of extremely low frequency electro magnetic field (ELF-EMF) (50 Hz, 0.97 mT) on 8OHdG levels in DNA and thiobarbituric acid reactive substances (TBARS) in plasma. To examine the possible time-dependent changes resulting from magnetic field, 8OHdG and TBARS were quantitated at 50 and 100 days. Our results showed that the exposure to ELF-EMF induced oxidative DNA damage and lipid peroxidation (LPO). The 8OHdG levels of exposed group (4.39±0.88 and 5.29±1.16 8OHdG/dG.105, respectively) were significantly higher than sham group at 50 and 100 days (3.02±0.63 and 3.46±0.38 8OHdG/dG.105) (p<0.001, p<0.001). The higher TBARS levels were also detected in the exposure group both on 50 and 100 days (p<0.001, p<0.001). In addition, the extent of DNA damage and LPO would depend on the exposure time (p<0.05 and p<0.05). Our data may have important implications for the long-term exposure to ELF-EMF which may cause oxidative DNA damage.KeywordsDNA damagemagnetic field8-hydroxy-2′-deoxyguanosine8-oxoguaninethiobarbituric acidTBARS
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