Portal de Periódicos da CAPES

Lateral gaze palsy due to giant aneurysm of the posterior fossa.

1988; BMJ; Volume: 51; Issue: 6 Linguagem: Inglês

10.1136/jnnp.51.6.883-a

1468-330X

David W. Morgan, W H Honan,

Meningioma and schwannoma management

Intracranial aneurysm and HLA-DR2Sir: The annual incidence of aneurysmal subarachnoid haemorrhage is approxi- mately 12 per 100,000,1 while intracranial aneurysms (ICAs) may be found in at least 5% of the population, ruptured and un- ruptured.2In spite of their common occur- rence, the pathogenesis of ICAs is poorly understood.A recent study by 0stergaard et al3 has provided tentative evidence of the existence of a genetic predisposition to ICA.In a group of 116 consecutive ICA patients no significant association could be found be- tween any of the HLA-A, B, and C antigens, but for HLA-B7 a significant deviation from the Hardy-Weimberg equilibrium with an increase of homozygotes was found.3Owing to linkage disequilibria this could indicate an association with HLA-DR2.Fifteen Danish ICA patients used as cadaver kidney donors were therefore examined and the HLA-DR2 frequency was found to be significantly increased (66-7% vs 29 7%).3To confirm or refute this association we have examined the HLA-DR2 frequency in a similar group of Dutch patients with proven ICA.The medical records of all patients with subarachnoid haemorrhage, admitted to the three neurosurgical centres in Amsterdam between January 1981 and January 1987 and used as cadaver kidney or multi-organ do- nors, were reviewed.The diagnosis of sub- arachnoid haemorrhage was confirmed by lumbar puncture or computed tomography.Thirty-one Caucasian patients with an an- giographically or necropsy proven ICA were included in this study.There were 21 women and 10 men, aged 16 to 64 years (mean 37-9 years).In 11 patients the ruptured aneurysm arose from the internal carotid artery, in nine from the anterior communicating artery, in seven from the middle cerebral artery and in four from the basilar artery.Multiple aneurysms were found in six patients.The control group consisted of 1269 healthy blood donors.Tissue typing was performed by means of standard lymphocytotoxic as- says.