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Spindle and epithelioid cell nevi in the adult.Clinicopathologic report of 26 cases

1967; Wiley; Volume: 20; Issue: 2 Linguagem: Inglês

10.1002/1097-0142(1967)20

1097-0142

Rene A. Echevarria, Lauren V. Ackerman,

Sarcoma Diagnosis and Treatment

CancerVolume 20, Issue 2 p. 175-189 ArticleFree Access Spindle and epithelioid cell nevi in the adult. Clinicopathologic report of 26 cases René Echevarria MD, René Echevarria MD Division of Surgical Pathology, Washington University School of Medicine, 660 South Euclid, St. Louis, Mo. 63110Search for more papers by this authorLauren V. Ackerman MD, Lauren V. Ackerman MD Division of Surgical Pathology, Washington University School of Medicine, 660 South Euclid, St. Louis, Mo. 63110Search for more papers by this author René Echevarria MD, René Echevarria MD Division of Surgical Pathology, Washington University School of Medicine, 660 South Euclid, St. Louis, Mo. 63110Search for more papers by this authorLauren V. Ackerman MD, Lauren V. Ackerman MD Division of Surgical Pathology, Washington University School of Medicine, 660 South Euclid, St. Louis, Mo. 63110Search for more papers by this author First published: 1967 https://doi.org/10.1002/1097-0142(1967)20:2 3.0.CO;2-JCitations: 62AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The spindle and epithelioid cell nevi occur in adults rarely but should not be confused with malignant melanomas. One criteria for differentiation is the homogeneity of the spindle cell nevus. Twenty-six of these lesions in adults were essentially similar histologically to those in children. Clinically the distribution also compares but the lesions tended to be more pigmented and often feared to be malignant. The nevus may arise de novo in adult life or may have been present since childhood and then grow and increase in pigmentation. In no instance was spontaneous ulceration present. The pure spindle cell nevus is the most frequent whereas pure spindle cell melanomas are rare. Pure epithelioid cell nevi were not found in adults. Adequate local excision is the treatment of choice. Local recurrence may follow inadequate excision but is not evidence of malignancy. References 1 Ackerman, L. V.: In Proceedings of the Twenty-second Seminar of the American Society of Clinical Pathologists. American Society of Clinical Pathologists, 1957; p. 65, Fig. 37. 2 Allen, A. C., and Spitz, S.: Malignant melanomas—A clinicopathologic analysis of the criteria for diagnosis and prognosis. Cancer 6: 1– 45, 1953. 3 Allen, A. C., and Spitz, S.: Juvenile melanoma and malignant melanoma. Surg. Gynec. Obstet. 104: 753– 754, 1957. 4 Allen, A. C., and Spitz, S.: Juvenile melanomas of children and adults and melanocarcinomas of children. AMA Arch. Dermatol. 82: 325– 335, 1960. 5 Allen, A. C., and Spitz, S.: Juvenile melanomas. In The Pigment Cell—Molecular, Biological and Clinical Aspects—Part I. Ann. N. Y. Acad. Sci. 100: 29– 48, 1963. 6 Duperrat, M. B.: The juvenile melanoma. Bul. Soc. Franc. Derm. Syph. 62: 500– 504, 1955. 7 Duperrat, M. B.: The juvenile melanoma. Bul. Soc. Franc. Derm. Syph. 62: 500– 504, and Mascaro, J. H.: Anatomoclinical study of four cases of Spitz tumor in adults. Bul. Soc. Franc. Derm. Syph. 68: 472– 478, 1961. 8 Gartmann, H.: Das sog. juvenile melanom. Munchen. Med. Wschr. 104: 587– 592, 1962. 9 Helwig, E. B., Seminar on skin neoplasms and dermatoses. In Proceedings of the 20th Seminar of the American Society of Clinical Pathologists, Sept. 11, 1954. American Society of Clinical Pathologists, 1955; p. 63– 67. 10 Kernen, J. A., and Ackerman, L. V.: Spindle cell nevi and epithelioid cell nevi (so-called juvenile melanoma) in children and adults—A clinicopathologic study. Cancer 13: 612– 625, 1960. 11 Kopf, A. W., and Andrade, R.: A histologic study of the dermoepidermal junction in clinically "intradermal nevi" employing serial sections—I. Junctional theques. In The Pigment Cells—molecular, biological and clinical aspects—Part I. Ann. N. Y. Acad. Sci. 100: 200– 218, 1963. 12 Lund, H. Z., and Kress, J. H.: Melanotic tumors of the skin. In Atlas of Tumor Pathology, sec. 1, fasc. 3, Washington, D. C. Armed Forces Institute of Pathology p. 51– 54. 13 McWhorter, H. E., and Woolner, L. B.: Pigmented nevi, juvenile melanomas and malignant melanomas in children. Cancer 7: 564– 585, 1954. 14 Schuhmachers-Brendler, R.: Beitrag zur klinik und histologie der naevocellulares—Sowie des juvenilen melanoms—II. Mitteilung—Die Sonderstellung des juvenilen melanoms— Arch. Klin. Exp. Derm. 217: 600– 626, 1963. 15 Spitz, S.: Melanomas of childhood. Am. J. Path. 24: 591– 609, 1948. Citing Literature Volume20, Issue21967Pages 175-189 ReferencesRelatedInformation