Portal de Periódicos da CAPES

Lipogenesis in developing guinea pig liver

1974; Elsevier BV; Volume: 3; Linguagem: Inglês

10.1016/0047-6374(74)90006-2

1872-6216

Mulchand S. Patel, Richard W. Hanson,

Liver Disease Diagnosis and Treatment

Hepatic fatty acid synthesis from glucose, pyruvate and acetate occurs at negligible levels in adult guinea pigs, whereas liver slices from fetal animals are able to synthesize fatty acids from acetate and pyruvate. However, glucose, pyruvate and acetate are readily oxidized to CO2 by liver slices from fetal, newborn and adult guinea pigs. Key enzymes in the metabolic sequence of fatty acid synthesis such as NADP-malate dehydrogenase and ATP-citrate lyase are virtually absent in liver from adult guinea pigs. A negligible incorporation of [3-14C]aspartate into fatty acids by adult guinea-pig liver suggest that carbon flow through the "citrate-malate cycle" is one of the limiting steps in lipogenesis in these animals. In contrast to the liver, adipose tissue from adult guinea-pigs actively synthesizes fatty acids from the various substrates used and has high levels of activity of the lipogenic enzymes measured. It is suggested that the capacity of the guinea-pig liver to synthesize fatty acids is negligible, and that this species differs from the rat and other non-ruminant animals studied to date.