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Flavonoids from Xyris species (Xyridaceae)

2002; Elsevier BV; Volume: 30; Issue: 10 Linguagem: Inglês

10.1016/s0305-1978(02)00035-2

1873-2925

Elenice Mouro Varanda, Carlo Rondinoni, Déborah Yara Alves Cursino dos Santos,

Sesquiterpenes and Asteraceae Studies

The ethanol extract from Xyris pteygoblephara aerial parts was evaluated against five microorganism strains, by the microdilution and agar diffusion methods. Extract fractionation led to the isolation of three compounds, whose structures were assigned by spectrometric data (1D and 2D NMR, IR, MS and UV) as (3R,4R)-(−)-6-methoxy-3,4-dihydro-3-n-pentil-4-acethoxy-1H-2-benzopyran-1-one (1), moronic acid and quercetin. The absolute configuration of 1 was defined by circular dichroism spectroscopy and comparison with data reported for other dihydroisocoumarins. Assay of 1 (100 μg/disc) by the agar diffusion method against clinical isolates of the dermatophytes Epidermophyton floccosum (inhibition zone, mm ± s.d.: 4.5 ± 0.8), Trichophyton mentagrophytes (4.8 ± 0.4) and Trichophyton rubrum (10.2 ± 0.8) revealed similar inhibition zones to the positive control amphotericin B (32 μg/disc; 5.0 ± 0.2; 5.0 ± 0.6 and 8.8 ± 1.2, respectively). The result corroborates the ethnomedical use of Xyris species to treat dermatitis.