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Reaction of 3-amino-1:2:4-triazole with bovine liver catalase and human erythrocyte catalase

1972; Elsevier BV; Volume: 148; Issue: 2 Linguagem: Inglês

10.1016/0003-9861(72)90169-5

1096-0384

Joyce Y. Chang, Werner Schroeder,

Protein Interaction Studies and Fluorescence Analysis

The stoichiometry of the reaction of 3-amino-1:2:4-triazole with catalase is different for bovine liver and human erythrocyte catalases, and can be correlated with the hematin content of the two types of catalase. A specific histidyl residue in catalase is modified, but an intact hematin appears to be necessary for binding of hydrogen peroxide before reaction with aminotriazole can occur.