Produção Nacional
Revisado por pares
Monocrotaline: Histological Damage and Oxidant Activity in Brain Areas of Mice
2012; Hindawi Publishing Corporation; Volume: 2012; Linguagem: Inglês
10.1155/2012/697541
ISSN1942-0900
AutoresJosé Eduardo Ribeiro Honório, Germana Silva Vasconcelos, Francisca Taciana Sousa Rodrigues, José Guedes de Sena Filho, José Maria Barbosa‐Filho, Carlos Clayton Torres Aguiar, Luzia Kalyne Almeida Moreira Leal, Pedro Marcos Gomes Soares, David Woods, Marta Maria de França Fonteles, Silvânia Maria Mendes Vasconcelos,
Tópico(s)Neuroinflammation and Neurodegeneration Mechanisms
ResumoThis work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25–30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were sacrificed by decapitation and the brain areas (HC, PHC, PFC, or ST) were removed for histopathological analysis or dissected and homogenized for measurement of OS parameters (lipid peroxidation, nitrite, and catalase) by spectrophotometry. Histological evaluation of brain structures of rats treated with MCT (50 and 100 mg/kg) revealed lesions in the hippocampus and parahippocampal cortex compared to control. Lipid peroxidation was evident in all brain areas after administration of MCT. Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. In conclusion, monocrotaline caused cell lesions in the hippocampus and parahippocampal cortex regions and produced oxidative stress in the HC, PFC, and ST in mice. These findings may contribute to the neurological effects associated with this compound.
Referência(s)