Revisão Revisado por pares

Classification of Hypersensitivity in Relation to Clinical Disease

1966; American College of Physicians; Volume: 64; Issue: 3 Linguagem: Inglês

10.7326/0003-4819-64-3-668

ISSN

1539-3704

Autores

Gunnar Bendixen,

Tópico(s)

Contact Dermatitis and Allergies

Resumo

Review1 March 1966Classification of Hypersensitivity in Relation to Clinical DiseaseGUNNAR BENDIXEN, M.D.GUNNAR BENDIXEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-3-668 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe word hypersensitivity in this paper indicates a state of specifically altered reactivity depending on an antigen-antibody reaction. According to this definition hypersensitivity covers a wide range of conditions corresponding to the concept of allergy as proposed by von Pirquet (1). As the word allergy has gradually lost its specific significance, it will not be used here.To evaluate diseases in which mechanisms of hypersensitivity are in action, a correct understanding of the nature of hypersensitive phenomena is necessary. Hypersensitivity as a basal biological phenomenon has lately attracted much attention in experimental medicine, and much new evidence has been accumulated....References1. PIRQUET CE: Allergy. Arch. Intern. Med. (Chicago) 7: 258, 1911. Google Scholar2. LANDSTEINERCHASE KMW: Experiments on transfer of cutaneous sensitivity to simple compounds. Proc. Soc. Exp. Biol. Med. 49: 688, 1942. CrossrefGoogle Scholar3. CHASE MW: The cellular transfer of cutaneous hypersensitivity to tuberculin. Proc. Soc. Exp. Biol. Med. 59: 134, 1945. CrossrefGoogle Scholar4. LAWRENCE HS: The transfer in humans of delayed skin sensitivity to streptococcal M-substance and to tuberculin with disrupted leucocytes. J. Clin. Invest. 34: 219, 1955. CrossrefMedlineGoogle Scholar5. LAWRENCE HE: Delayed hypersensitivity and the behaviour of the cellular transfer system in animal and man, in Mechanisms of Hypersensitivity, edited by SHAEFFER, J. H., LOGRIPPO, G. A., CHASE, M. W. J. & A. Churchill Ltd., London, 1959, p. 453. Google Scholar6. LAWRENCE HS: The transfer of hypersensitivity of the delayed type in man, in Cellular and Humoral Aspects of the Hypersensitive States, edited by LAWRENCE, H. S. Hoeber-Harper, New York, 1959, p. 279. Google Scholar7. WESSLÉN T: Passive transfer of tuberculin hypersensitivity by viable lymphocytes from the thoracic duct. Acta Tuberc. Scand. 26: 38, 1952. MedlineGoogle Scholar8. SALVIN SB: Designated discussion, in Mechanisms of Hypersensitivity, edited by SHAEFFER, J. H., LOGRIPPO, G. A., CHASE, M. W. J. & A. Churchill Ltd., London, 1959, p. 450. Google Scholar9. BAERSULTZBERGER RLMB: Attempts at passive transfer of allergic, eczematous sensitivity in man by means of white cell suspensions. J. Invest. Derm. 19: 217, 1952. CrossrefMedlineGoogle Scholar10. HAXTHAUSEN H: Attempts on passive, local sensitization by intracutaneous injection of cells from freshly excised lymph nodes of eczema allergics. J. Invest. Derm. 21: 237, 1953. CrossrefMedlineGoogle Scholar11. EPSTEINKLIGMAN WLAM: Transfer of allergic contact-type delayed sensitivity in man. J. Invest. Derm. 28: 291, 1957. CrossrefMedlineGoogle Scholar12. MITCHISON NA: Passive transfer of transplantation immunity. Proc. Roy. Soc. Biol. 142: 72, 1954. Google Scholar13. MITCHISON NA: Passive transfer of transplantation immunity. Nature (London) 171: 267, 1953. CrossrefMedlineGoogle Scholar14. CUMMINGSPATNODEHUDGINS MMRAPC: Passive transfer of tuberculin hypersensitivity in guinea pigs using cells disrupted by sonic vibration. Amer. Rev. Tuberc. 73: 246, 1956. Google Scholar15. LAWRENCE HS: Some biological and immunological properties of transfer factor, in Ciba Foundation Symposium on Cellular Aspects of Immunity, edited by WOLSTENHOLME, G. E. W., O'CONNOR, M. J. & A. Churchill Ltd., London, 1960, p. 243. CrossrefGoogle Scholar16. MCMASTER PD: General and local vascular reactions in certain states of hypersensitivity, in Cellular and Humoral Aspects of the Hypersensitive States, edited by LAWRENCE, H. S. Hoeber-Harper, New York, 1959, p. 319. Google Scholar17. KAPLANDIENES MHL: The cellular response in forms of delayed- and immediate-type skin reactions in the guinea pig, in Mechanisms of Hypersensitivity, edited by SHAEFFER, J. H., LOGRIPPO, G. A., CHASE, M. W. J. & A. Churchill Ltd., London, 1959, p. 435. Google Scholar18. WAKSMAN BH: A comparative histopathological study of delayed hypersensitive reactions, in Ciba Foundation Symposium on Cellular Aspects of Immunity, edited by WOLSTENHOLME, G. E. W., O'CONNOR, M. J. & A. Churchill Ltd., London, 1960, p. 280. CrossrefGoogle Scholar19. WAKSMAN BH: Tissue damage in the "delayed" (cellular) type of hypersensitivity, in Mechanism of Cell and Tissue Damage Produced by Immune Reactions, edited by GRABAR, P., MIESCHER, P. B. Schwabe & Co., Basel, 1962, p. 146. Google Scholar20. BENACERRAFMCCLUSKEY BRT: Methods of immunologic injury to tissues. Ann. Rev. Microbiol. 17: 263, 1963. CrossrefMedlineGoogle Scholar21. Nomenclature for human immunoglobulins. Bull. WHO 30: 447, 1964. MedlineGoogle Scholar22. HEREMANS JF: Les Globulines Sériques du Système Gamma. Leur Nature et Leur Pathologie. Arscia, Brussels, 1960. Google Scholar23. HEREMANSHEREMANS JFM: Studies on "abnormal" serum globulins (M-components) in myeloma, macroglobulinaemia and related diseases. Immunoelectrophoresis. Acta Med. Scand. (supplement) 367: 27, 1961. Google Scholar24. HEREMANSVAERMANCARBONARARODHAINHEREMANS JFJAOJAM: γ1A-globulin (β2A-globulin): its isolation, properties, functions and pathology, in Protides of the Biological Fluids, vol. 10, edited by PEETERS, H. Elsevier, Amsterdam, 1963, p. 108. Google Scholar25. GOULLET P: Biosynthèse des anticorps sériques. Presse Méd. 73: 1573, 1965. MedlineGoogle Scholar26. TREVORROWMERRILLCLAMAN VEDHN: Immunoglobulin components of "gamma" globulin in human serum. Clin. Chem. 11: 527, 1965. CrossrefMedlineGoogle Scholar27. FAGRAEUS A: Antibody Production in Relation to the Development of Plasma Cells (thesis). Stockholm, 1948. Google Scholar28. NOSSALMÄKELÄ GJO: Elaboration of antibodies by single cells. Ann. Rev. Microbiol. 16: 53, 1962. CrossrefMedlineGoogle Scholar29. NOSSALSZENBERGADAAUSTIN GJAGLCM: Single cell studies on 19S antibody production. J. Exp. Med. 119: 485, 1964. CrossrefMedlineGoogle Scholar30. MUDD S: A hypothetical mechanism of antibody formation. J. Immun. 23: 423, 1932. Google Scholar31. PAULING L: A theory of the structure and process of formation of antibodies. J. Amer. Chem. Soc. 62: 2643, 1940. CrossrefGoogle Scholar32. KARUSH F: Specificity of antibodies. Trans. N. Y. Acad Sci. 20: 581, 1958. CrossrefMedlineGoogle Scholar33. BURNETFENNER FMF: The Production of Antibodies. Macmillan and Co., Melbourne, 1949. Google Scholar34. SCHWEETOWEN RSRD: Concepts of protein synthesis in relation to antibody formation. J. Cell. Comp. Physiol. (supplement) 50: 199, 1957. CrossrefMedlineGoogle Scholar35. JERNE NK: The natural selection theory of antibody formation. Proc. Nat. Acad. Sci. 41: 849, 1955. CrossrefMedlineGoogle Scholar36. BURNET FM: The Clonal Selection Theory of Acquired Immunity. Cambridge University Press, Cambridge, 1959. CrossrefGoogle Scholar37. CARPENTER PL: Immunology and Serology. W. B. Saunders Co., Philadelphia, 1965. Google Scholar38. HOLUBJAROŠKOVÁ ML: Mechanisms of antibody formation. Symposium, Prague, 1960. Google Scholar39. WOLSTENHOLME GE (editor): The Immunologically Competent Cell: Its Nature and Origin. Ciba foundation study group no. 16. J. & A. Churchill Ltd., London, 1963 Google Scholar40. PAPERMASTERCONDIEFINSTADGOOD BWRMJRA: Evolution of the immune response. I. The phylogenetic development of adaptive immunologic responsiveness in vertebrates. J. Exp. Med. 119: 105, 1964. CrossrefMedlineGoogle Scholar41. GÜNTHER O: Die entwicklung der Immunität. Deutsch. Med. Wschr. 89: 2449, 1964. CrossrefMedlineGoogle Scholar42. WOLSTENHOLMEO'CONNOR GEM (editors): Ciba Foundation Symposium on Cellular Aspects of Immunity. J. & A. Churchill Ltd., London, 1960. CrossrefGoogle Scholar43. MANNICKEGDAHL JARH: Transfer of heightened immunity to skin homografts by lymphoid RNA. J. Clin. Invest. 43: 2166, 1964. CrossrefMedlineGoogle Scholar44. CROWLE AJ: Delayed hypersensitivity in health and disease. Charles C Thomas, publisher, Springfield, Ill., 1962. Google Scholar45. LAWRENCE HS (editor): Cellular and humoral aspects of the hypersensitive states. Hoeber-Harper, New York, 1959. Google Scholar46. SHAEFFERLOGRIPPOCHASE JHGAMW (editors): Mechanisms of hypersensitivity. J. & A. Churchill Ltd., London, 1959. Google Scholar47. RAFFEL S: Immunity, Hypersensitivity, Serology. Appleton-Century-Crofts, New York, 1953. Google Scholar48. ARTHUS M: Injections repétées de serum de cheval chez le lapin. C. R. Soc. Biol. (Paris) 55: 817, 1903. Google Scholar49. OPIE EL: Inflammatory reaction of the immune animal to antigen (Arthus' phaenomenon) and its relation to antibodies. J. Immun. 9: 231, 1924. Google Scholar50. CANNONMARSHALL PRCE: Studies on the mechanism of the Arthus phaenomenon. J. Immun. 40: 127, 1941. Google Scholar51. BENACERRAFKABAT BEA: A quantitative study of the Arthus phaenomenon induced passively in the guinea pig. J. Immun. 64: 1, 1950. MedlineGoogle Scholar52. KUHNS WJ: Immunochemical studies of antitoxin produced in normal and allergic individuals hyperimmunized with diphtheria toxoid. J. Exp. Med. 97: 903, 1953. CrossrefMedlineGoogle Scholar53. DALE HH: The anaphylactic reaction of plain muscle in the guinea-pig. J. Pharmacol. Exp. Ther. 4: 137, 1913. Google Scholar54. FREUNDWHITNEY JCE: Distribution of antibodies in the serum and organs of rabbits. J. Immun. 15: 369, 1928. Google Scholar55. SCHILD HO: Mechanism of the anaphylactic reaction as studied by means of inhibitors, in Mechanisms of Hypersensitivity, edited by SHAEFFER, J. H., LOGRIPPO, G. A., CHASE, M. W. J. & A. Churchill Ltd., London, 1959, p. 243. Google Scholar56. HUMPHREY JH: Biochemical aspects of reactions in hypersensitive responses, in Cellular and Humoral Aspects of the Hypersensitive States, edited by LAWRENCE, H. S. Hoeber-Harper, New York, 1959, p. 1. Google Scholar57. WAKSMAN BH: The toxic effects of the antigen-antibody reaction on the cells of hypersensitive reactors. Ibid., p. 123. Google Scholar58. HALPERNLIACOPOULOSBINAGHILIACOPOULOS-BRIOT BNMRM: The patterns and mechanism of fixation of anaphylactic antibody on living tissues in vitro, in Ciba Foundation Symposium on Cellular Aspects of Immunity. J. & A. Churchill Ltd., London, 1960, p. 409. CrossrefGoogle Scholar59. AUSTENHUMPHREY KFJH: Mechanism of the anaphylactic release of histamine and slow reacting substance, in Mechanism of Cell and Tissue Damage Produced by Immune Reactions, edited by GRABAR, P., MIESCHER, P. B. Schwabe & Co., Basel, 1962, p. 93. Google Scholar60. BROCKLEHURST WE: Pharmacological mediators of hypersensitivity reactions, in Clinical Aspects of Immunology, edited by GELL, P. G. H., COOMBS, R. R. A. Blackwell Scientific Publications, Oxford, 1963, p. 360. Google Scholar61. OVARY Z: Passive cutaneous anaphylaxis. Immunological Methods, edited by ACKROYD, J. F. Blackwell Scientific Publications, Oxford, 1964, p. 259. Google Scholar62. FRANKLAND AW: The pathogenesis of asthma, hayfever and atopic diseases, in Clinical Aspects of Immunology, edited by GELL, P. G. H., COOMBS, R. R. A. Blackwell Scientific Publications, Oxford, 1963, p. 338. Google Scholar63. KUHNS WJ: Certain forms of hypersensitivity in man mediated by antigen-antibody reactions, in Cellular and Humoral Aspects of the Hypersensitive States, edited by LAWRENCE, H. S. Hoeber-Harper, New York, 1959, p. 535. Google Scholar64. DEGARA PF: The hereditary predisposition in man to develop hypersensitivity. A critical review, in Mechanisms of Hypersensitivity, edited by SHAEFFER, J. H., LOGRIPPO, G. A., CHASE, M. W. J. & A. Churchill Ltd., London, 1959, p. 703. Google Scholar65. AUGUSTINHAYWARD RBJ: Human reagins to grass pollens and moulds: their purification and physico-chemical characterization. Immunology 3: 45, 1960. MedlineGoogle Scholar66 STAVITSKY AB: Haemagglutination and haemagglutination-inhibition reactions with tannic acid- and bis-diazotized benzidine-protein-conjugated erythrocytes, in Immunological Methods, edited by ACKROYD, J. F. Blackwell Scientific Publications, Oxford, 1964. Google Scholar67. PATTERSONFINKNISHIMURAPRUZONSKY RJNETJJ: The passive transfer of immediate type hypersensitivity from man to other primates. J. Clin. Invest. 44: 140, 1965. CrossrefMedlineGoogle Scholar68. COOMBSGELL RRPG: The classification of allergic reactions underlying disease, in Clinical Aspects of Immunology, edited by GELL, P. G. H., COOMBS, R. R. A. Blackwell Scientific Publications, Oxford, 1963, p. 317. Google Scholar69. ZINSSER H: Studies on the tuberculin reaction and on specific hypersensitiveness in bacterial infection. J. Exp. Med. 34: 495, 1921. CrossrefMedlineGoogle Scholar70. DIENES L: The immunological significance of the tuberculous tissue. J. Immun. 15: 141, 1928. Google Scholar71. JENSEN KA: Rélation entre l'Allergie et l'Immunité dans la Tuberculose. VII conférence de l'union internationale contre la tuberculose, 1932, p. 71. Google Scholar72. JENSENBINDSLEVHOLM KAGJ: Experimental studies on the development of tuberculous infection in allergic and non-allergic animals. Acta Tuberc. Scand. 9: 27, 1935. Google Scholar73. JENSENBINDSLEV KAG: Experimental studies on the development of tuberculous infection in allergic and non-allergic animals. Acta Tuberc. Scand. 11: 101, 1937. Google Scholar74. RAFFEL S: The components of the tubercle bacillus responsible for the delayed type of infectious allergy. J. Infect. Dis. 82: 267, 1948. CrossrefMedlineGoogle Scholar75. RICH AR: The Pathogenesis of Tuberculosis, 2nd ed. Charles C Thomas, Publisher, Springfield, Ill., 1951. Google Scholar76. CROWLE AJ: Immunizing constituents of the tubercle bacillus. Bact. Rev. 22: 183, 1958. CrossrefMedlineGoogle Scholar77. BENDIXEN G: Undersøgelser af Hypersensibilitetsproblemet (thesis). Munksgaard, Copenhagen, 1962. Google Scholar78. BENDIXEN G: The influence of tuberculolipids on the type of hypersensitivity. Acta Path. Microbiol. Scand. 57: 222, 1963. CrossrefMedlineGoogle Scholar79. JONESMOTE TRJ: The phases of foreign protein sensitization in human beings. New Eng. J. Med. 210: 120, 1934. CrossrefGoogle Scholar80. UHRSALVINPAPPENHEIMER JWSBAM: Induction of delayed hypersensitivity in guinea pigs by means of antigen-antibody complexes. J. Exp. Med. 105: 11, 1957. CrossrefMedlineGoogle Scholar81. SALVIN SB: Occurrence of delayed hypersensitivity during the development of Arthus type hypersensitivity. J. Exp. Med. 107: 109, 1958. CrossrefMedlineGoogle Scholar82. PAPPENHEIMERSCHARFUHR AMMJW: Delayed hypersensitivity and its possible relation to antibody formation, in Mechanisms of Hypersensitivity, edited by SHAEFFER, J. H., LOGRIPPO, G. A., CHASE, M. W. J. & A. Churchill Ltd., London, 1959, p. 417. Google Scholar83. KAPLANDIENES MHL: The cellular response in forms of delayed- and immediate-type sin reactions in the guinea pig. Ibid., p. 435. Google Scholar84. PAPPENHEIMERFREUND AMJ: Induction of delayed hypersensitivity to protein antigens, in Cellular and Humoral Aspects of the Hypersensitive States, edited by LAWRENCE, H. S. Hoeber-Harper, New York, 1959, p. 67. Google Scholar85. EISEN HN: Hypersensitivity to simple chemicals. Ibid., p. 89. Google Scholar86. KLIGMANEPSTEIN AMWL: Some factors affecting contact sensitization in man, in Mechanisms of Hypersensitivity, edited by SHAEFFER, J. H., LOGRIPPO, G. A., CHASE, M. W. J. & A. Churchill Ltd., London, 1959, p. 713. Google Scholar87. CHASEBATTISTO MWJR: Immunologic unresponsiveness to simple chemicals. Ibid., p. 507. Google Scholar88. CALNAN CD: Allergic contact dermatitis, in Clinical Aspects of Immunology, edited by GELL, P. G. H., COOMBS, R. R. A. Blackwell Scientific Publications, Oxford, 1963, p. 514. Google Scholar89. BATTISTOCHASE JRMW: Induced unresponsiveness to simple allergenic chemicals. II. Independence of delayed-type hypersensitivity and formation of circulating antibody. J. Exp. Med. 121: 591, 1965. CrossrefMedlineGoogle Scholar90. MEDAWAR PB: The immunity of transplantation. Harvey Lect. 52: 144, 1956-57. Google Scholar91. BRENT L: Tissue transplantation immunity. Progr. Allerg. 5: 271, 1958. MedlineGoogle Scholar92. BRENT L: Transplantation, immunity and hypersensitivity, in Mechanisms of Hypersensitivity, edited by SHAEFFER, J. H., LOGRIPPO, G. A., CHASE, M. W. J. & A. Churchill Ltd., London, 1959, p. 555. Google Scholar93. MEDAWAR PB: Reactions to homologous tissue antigens in relation to hypersensitivity, in Cellular and Humoral Aspects of the Hypersensitive States, edited by LAWRENCE, H. S. Hoeber-Harper, New York, 1959, p. 504. Google Scholar94. STETSON CA: The role of antibody in the rejection of homografts, in Mechanisms of Hypersensitivity, edited by SHAEFFER, J. H., LOGRIPPO, G. A., CHASE, M. W. J. & A. Churchill Ltd., London, 1959, p. 569. Google Scholar95. LAWRENCE HS: Delayed bacterial allergy, homograft sensitivity and autoimmune disease. Expressions of the immunologic origins and consequences of individuality. New York J. Med. 62: 356, 1962. MedlineGoogle Scholar96. LAWRENCERAPAPORTCONVERSETILLETT HSFTJMWS: A mechanism of homograft rejection, in Mechanism of Cell and Tissue Damage Produced by Immune Reactions, edited by GRABAR, P., MIESCHER, P. B. Schwabe & Co., Basel, 1962, p. 204. Google Scholar97. NELSON RA: Immunologic mechanisms for homograft and heterograft rejections. Ibid., p. 223. Google Scholar98. BILLINGHAMSILVERS REWK: Sensitivity to homografts of normal tissues and cells. Ann. Rev. Microbiol. 17: 531, 1963. CrossrefMedlineGoogle Scholar99. BILLINGHAM RE: Transplantation immunity and the maternal-fetal relation. New Eng. J. Med. 270: 667, 720, 1964. CrossrefMedlineGoogle Scholar100. RUSSELLMONACO PSAP: The biology of tissue transplantation. New Eng. J. Med. 271: 502, 553, 610, 664, 718, 776; 1964. CrossrefMedlineGoogle Scholar101. WAKSMAN BH: Experimental allergic encephalomyelitis as prototype of the class of autoallergic diseases, in Mechanisms of Hypersensitivity, edited by SHAEFFER, J. H., LOGRIPPO, G. A., CHASE, M. W. J. & A. Churchill Ltd., London, 1959. Google Scholar102. WAKSMAN BH: Tubercle bacillus lipopolysaccharide as adjuvant in the production of experimental, allergic encephalomyelitis in rabbits. J. Infect. Dis. 93: 21, 1953. CrossrefMedlineGoogle Scholar103. MACKAYBURNET IRFM: Autoimmune Diseases. Charles C Thomas, publisher, Springfield, Ill., 1963. Google Scholar104. PATERSON PY: Organ-specific tissue damage induced by mammalian tissue-adjuvant emulsions, in Cellular and Humoral Aspects of the Hypersensitive States, edited by LAWRENCE, H. S. Hoeber-Harper, New York, 1959, p. 469. Google Scholar105. CRUICKSHANK B: Autoallergic reactions of brain, testis, liver, pancreas and skeletal muscle, in Clinical Aspects of Immunology, edited by GELL, P. G. H., COOMBS, R. R. A. Blackwell Scientific Publications, Oxford, 1963, p. 633. Google Scholar106. GRABARMIESCHER PP (editors): Mechanism of Cell and Tissue Damage Produced by Immune Reactions. B. Schwabe & Co., Basel, 1962. Google Scholar107. GELLCOOMBS PGRR (editors): Clinical Aspects of Immunology. Blackwell Scientific Publications, Oxford, 1962. Google Scholar108. CRUICKSHANK B: Nephritis, nephrosis, rheumatic fever and myocardial infarction, in Clinical Aspects of Immunology, edited by GELL, P. G. H., COOMBS, R. R. A. Blackwell Scientific Publications, Oxford, 1963, p. 572. Google Scholar109. SILVERSTEIN AM: Allergic reactions of the eye. Ibid., p. 555. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GUNNAR BENDIXEN, M.D.Affiliations: Copenhagen,From the University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.Requests for reprints should be addressed to Gunnar Bendixen, M.D., University Hospital of Copenhagen, Rigshospitalet, Copenhagen Ø Denmark. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAspects of science in Scandinavian rheumatology the making of a specialtyThe respiratory tract and the environment.Response of the lung to inhaled antigensEignet sich der Makrophagen-Migrationshemmtest zur Untersuchung der vakzinalen Gewebeimmunität?EVALUATION OF THE PRIMARY IMMUNE RESPONSE IN UREMIA AND AFTER EXTRACORPOREAL IRRADIATION OF THE BLOODVeränderungen im Spiegel des Serotonins und Bradykininogens und der Oxydaseaktivität des Ceruloplasmins beim experimentellen infektiös-allergischen (rheumatischen) EncephalitismodellTHE SEROLOGICAL DIAGNOSIS OF PENICILLIN ALLERGYA Concept of Allergy with Reference to Oral DiseaseImmunity and oral disease: a synopsis of the science of immunityORGAN-SPECIFIC INHIBITION OF THE IN VITRO MIGRATION OF LEUCOCYTES IN HUMAN GLOMERULONEPHRITISDelayed Hypersensitivity Reactions in the Intestinal TractImmunological Aspects of NeoplasiaHuman Lymphocyte Migration as a Parameter of HypersensitivitySome Common Allergic Emergencies 1 March 1966Volume 64, Issue 3Page: 668-686KeywordsAllergy and immunologyAntigensBiologicsHypersensitivityPathogenesisPathogensTransplantation ePublished: 1 December 2008 Issue Published: 1 March 1966 PDF downloadLoading ...

Referência(s)