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IgM binding to sialosyllactosaminylparagloboside in a patient with polyradiculoneuropathy due to Mycoplasma pneumoniae infection

1988; Wiley; Volume: 78; Issue: 1 Linguagem: Inglês

10.1111/j.1600-0404.1988.tb03619.x

1600-0404

Takashi Inuzuka, Nobuyuki Miyatani, Hiroko Baba, Masami Tanaka, Kenichi Tanaka, Shuzo Sato, Kyoko Nakamura, T. Miyatake,

Glycosylation and Glycoproteins Research

IgM in serum without paraprotein in a patient with polyradiculoneuropathy due to a Mycoplasma pneumoniae infection reacted specifically with a ganglioside, sialosyllactosaminylparagroboside (SLPG), in a human peripheral nerve on a thin-layer chromatogram plate by an immunostaining technique. This finding suggests the possibility that anti-SLPG antibody in the patient's serum may play a role in the pathogenesis of neuropathy.