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Feasibility of a Miniature Centrifugal Rotary Blood Pump for Low-Flow Circulation in Children and Infants

2005; Lippincott Williams & Wilkins; Volume: 51; Issue: 5 Linguagem: Inglês

10.1097/01.mat.0000176139.01152.5b

1538-943X

Setsuo Takatani, Hideo Hoshi, Kennichi Tajima, Katsuhiro Ohuchi, Makoto Nakamura, Junichio Asama, Tadahiko Shimshi, Masaharu Yoshikawa,

Congenital Heart Disease Studies

In this study, a seal-less, tiny centrifugal rotary blood pump was designed for low-flow circulatory support in children and infants. The design was targeted to yield a compact and priming volume of 5 ml with a flow rate of 0.5–4 l/min against a head pressure of 40–100 mm Hg. To meet the design requirements, the first prototype had an impeller diameter of 30 mm with six straight vanes. The impeller was supported with a needle-type hydrodynamic bearing and was driven with a six-pole radial magnetic driver. The external pump dimensions included a pump head height of 20 mm, diameter of 49 mm, and priming volume of 5 ml. The weight was 150 g, including the motor driver. In the mock circulatory loop, using fresh porcine blood, the pump yielded a flow of 0.5–4.0 l/min against a head pressure of 40–100 mm Hg at a rotational speed of 1,800–4,000 rpm using 1/4” inflow and outflow conduits. The maximum flow and head pressure of 5.25 l/min and 244 mm Hg, respectively, were obtained at a rotational speed of 4,400 rpm. The maximum electrical-to-hydraulic efficiency occurred at a flow rate of 1.5–3.5 l/min and at a rotational speed of 2,000–4,400 rpm. The normalized index of hemolysis, which was evaluated using fresh porcine blood, was 0.0076 g/100 l with the impeller in the down-mode and a bearing clearance of 0.1 mm. Further refinement in the bearing and magnetic coupler are required to improve the hemolytic performance of the pump. The durability of the needle-type hydrodynamic bearing and antithrombotic performance of the pump will be performed before clinical applications. The tiny centrifugal blood pump meets the flow requirements necessary to support the circulation of pediatric patients.