Portal de Periódicos da CAPES

Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development

2008; Elsevier BV; Volume: 373; Issue: 4 Linguagem: Inglês

10.1016/j.bbrc.2008.06.088

1090-2104

Minoru Takasato, Chiyoko Kobayashi, Koji Okabayashi, Hiroshi Kiyonari, Naoko Oshima, Makoto Asashima, Ryuichi Nishinakamura,

Birth, Development, and Health

Glomeruli comprise an important filtering apparatus in the kidney and are derived from the metanephric mesenchyme. A nuclear protein, Sall1, is expressed in this mesenchyme, and we previously reported that Trb2, a mouse homolog of Drosophila tribbles, is expressed in the mesenchyme-derived tissues of the kidney by microarray analyses using Sall1-GFP knock-in mice. In the present report, we detected Trb2 expression in a variety of organs during gestation, including the kidneys, mesonephros, testes, heart, eyes, thymus, blood vessels, muscle, bones, tongue, spinal cord, and ganglions. In the developing kidney, Trb2 signals were detected in podocytes and the prospective mesangium of the glomeruli, as well as in ureteric bud tips. However, Trb2 mutant mice did not display any apparent phenotypes and no proteinuria was observed, indicating normal glomerular functions. These results suggest that Trb2 plays minimal roles during kidney and mouse development.