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Concanavalin A in vivo: Induction of Hemorrhagic Skin Lesions (Arthus-Like Reactions) in Mice

1968; American Association for the Advancement of Science; Volume: 160; Issue: 3825 Linguagem: Inglês

10.1126/science.160.3825.312

1095-9203

Leon S. Kind, W Petersen,

Plant Reproductive Biology

Concanavalin A injected into the skin of mice induced the formation of hemorrhagic Arthus-like lesions. No lesions resulted if concanavalin A was adsorbed with insoluble (a2)- macroglobulin or if mice were first treated with nitrogen mustard. The ability of concanavalin A, phytohemagglutinin, or pokeweed mitogen to induce skin lesions seemed to parallel their ability to precipitate serum proteins.