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Promoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients

2011; Springer Nature; Volume: 104; Issue: 12 Linguagem: Inglês

10.1038/bjc.2011.165

1532-1827

James B. Rawson, Miralem Mrkonjic, Darshana Daftary, Elizabeth Dicks, Daniel D. Buchanan, H. Banfield Younghusband, Patrick S. Parfrey, Joanne Young, Aaron Pollett, R. C. Green, Steven Gallinger, John McLaughlin, Julia A. Knight, Bharati Bapat,

Wnt/β-catenin signaling in development and cancer

In colorectal cancer (CRC), tumour microsatellite instability (MSI) status and CpG island methylator phenotype (CIMP) status are indicators of patient outcome, but the molecular events that give rise to these outcomes remain largely unknown. Wnt5a is a critical regulator of non-canonical Wnt activity and promoter hypermethylation of this gene has emerging prognostic roles in CRC; however the frequency and prognostic significance of this epigenetic event have not been explored in the context of colorectal tumour subtype. Consequently, we investigated the frequency and prognostic significance of Wnt5a methylation in a large cohort of MSI-stratified CRCs.