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A first-generation linkage disequilibrium map of human chromosome 22

2002; Nature Portfolio; Volume: 418; Issue: 6897 Linguagem: Inglês

10.1038/nature00864

1476-4687

Elisabeth Dawson, Gonçalo R. Abecasis, Suzannah Bumpstead, Yuan Chen, Sarah Hunt, David Beare, Jagjit Pabial, Thomas Dibling, Emma Tinsley, Susan Kirby, Emma Carter, Marianna Papaspyridonos, Simon Livingstone, Rocky Ganske, Elin Lõhmussaar, Jana Zernant, Neeme Tõnisson, Maido Remm, Reedik Mägi, Tarmo Puurand, Jaak Vilo, Ants Kurg, Kate Rice, Panos Deloukas, Richard Mott, Andres Metspalu, David Bentley, Lon R. Cardon, Ian Dunham,

Genomics and Chromatin Dynamics

DNA sequence variants in specific genes or regions of the human genome are responsible for a variety of phenotypes such as disease risk or variable drug response1. These variants can be investigated directly, or through their non-random associations with neighbouring markers (called linkage disequilibrium (LD))2,3,4,5,6,7,8. Here we report measurement of LD along the complete sequence of human chromosome 22. Duplicate genotyping and analysis of 1,504 markers in Centre d'Etude du Polymorphisme Humain (CEPH) reference families at a median spacing of 15 kilobases (kb) reveals a highly variable pattern of LD along the chromosome, in which extensive regions of nearly complete LD up to 804 kb in length are interspersed with regions of little or no detectable LD. The LD patterns are replicated in a panel of unrelated UK Caucasians. There is a strong correlation between high LD and low recombination frequency in the extant genetic map, suggesting that historical and contemporary recombination rates are similar. This study demonstrates the feasibility of developing genome-wide maps of LD.