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From Galvani to patch clamp: the development of electrophysiology

2006; Springer Science+Business Media; Volume: 453; Issue: 3 Linguagem: Inglês

10.1007/s00424-006-0169-z

1432-2013

Alexei Verkhratsky, Oleg Krishtal, Ole H. Petersen,

Neural dynamics and brain function

The development of electrophysiology is traced from the early beginnings represented by the work of the Dutch microscopist, Jan Swammerdam, in the 17th century through the first notion of an aqueous transmembrane pore as a substrate of excitability made by Luigi Galvani in late 18th century to the invention late in the 20th century of the patch-clamp technique by Erwin Neher and Bert Sakmann.